Reacción #1166472

Ecuación de reacción

2-(methylamino)ethanol

furoyl chloride

→

N-(2-hydroxyethyl)-N-methylfuranamide

Rendimiento 57.6%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA one liter, three necked flask was equipped with overhead stirrer
2. 2
   TemperaturaThe reaction flask was cooled with an ice bath
3. 3
   LavadoThe dichloromethane was washed with NaCl(aq.)
4. 4
   ExtracciónNext, the NaCl(aq.) layer was extracted with dichloromethane
5. 5
   Secadodried over MgSO4
6. 6
   OtroThe dichloromethane was removed with a rotoevaporator

Procedimiento

A one liter, three necked flask was equipped with overhead stirrer, nitrogen atmosphere and an addition funnel. The flask was charged with 115 g of 2-(methylamino)ethanol (1.53 mol.) and 500 ml of dichloromethane. The reaction flask was cooled with an ice bath. Next, 100 g of furoyl chloride (0.77 mol.) was slowly added via the addition funnel over 2.5 hours. The dichloromethane was washed with NaCl(aq.). Next, the NaCl(aq.) layer was extracted with dichloromethane and the two dichloromethane layers were combined and dried over MgSO4. The dichloromethane was removed with a rotoevaporator to yield 75 g (44%) of N-(2-hydroxyethyl)-N-methylfuranamide.

Fuente