Reacción #1154345

ord-35d26ea3d04d43a59978e30abc855c17

Ecuación de reacción

Cl
HCl
N=C(N)NCCC[C@H](N)C(=O)O
arginine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1
ceftriaxone
N=C(N)NCCC[C@H](N)C(=O)O
arginine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1
ceftriaxone
N=C(N)NCCC[C@H](N)C(=O)O
arginine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.N=C(N)NCCC[C@H](N)C(=O)O
ceftriaxone arginine

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

About 582 mg (3.34 mole) of particulate arginine was dissolved in 50 ml of distilled water. Additionally, about 1.0 grams (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N-HCl until the pH reached 6.0. The ceftriaxone solution was then added to the arginine solution and stirred by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-arginine solution. To the ceftriaxone-arginine solution was added about 400 mg of carrageenan and the solution was stirred by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-arginine-carrageenan complex was formed which was freeze-dried while in the swollen state, yielding about 1.84 g of the freeze dried complex.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06248360B1uspto-grants-2001_06