Reacción #1154124

ord-2766b7fa609e46f3a833c8556330b8d3

Ecuación de reacción

CC(C)(CC(=O)C(=O)Nc1ccc2c(c1Br)COC2=O)c1ccccc1
4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide
Nc1ccc2c(c1)COC2=O
5-aminophthalide
C=CC(C)(C)CC(=O)C(=O)O
4,4-dimethyl-2-oxo-5-hexenoic acid
→
C=CC(C)(C)CC(=O)C(=O)Nc1ccc2c(c1)C(=O)OC2
6-(4,4-Dimethyl-2-oxo-5-hexenoylamino)-phthalide

Reactantes

CC(C)(CC(=O)C(=O)Nc1ccc2c(c1Br)COC2=O)c1ccccc1
4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide
Nc1ccc2c(c1)COC2=O
5-aminophthalide
C=CC(C)(C)CC(=O)C(=O)O
4,4-dimethyl-2-oxo-5-hexenoic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrowas obtained analogously to the process that

Procedimiento

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 5-aminophthalide and 4,4-dimethyl-2-oxo-5-hexenoic acid, melting point 103-104° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06245804B1uspto-grants-2001_06