Reacción #1148661

Ecuación de reacción

carbanion

[bis(triethoxysilyl)methyl]lithium

bromine

→

bis(triethoxysilyl)methylbromide

Rendimiento 86.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITat RT for 2 hrs
2. 2
   Extracciónthe product was further extracted with dry pentane
3. 3
   workup.DISTILLATIONThe residue was distilled under vacuum

Procedimiento

To the lithiated carbanion solution prepared in Example 1 above, a slight excess of bromine (1.5 g, 9.4 mmol) at −78° C. was added. The solution was stirred at −78° C. for 30 minutes and then at RT for 2 hrs. The solvent was pumped off and the product was further extracted with dry pentane. The residue was distilled under vacuum resulting in bis(triethoxysilyl)methylbromide (86% yield): boiling point 144–148° C. at 0.04 mm Hg; 1H NMR (300 MHz, CDCl3) δ 0.55–0.58 (t, 1 H, CHSi), δ 1.18–1.23 (q,18H, CH3) δ 2.89–2.92 (d, 2H, CH2Ph), δ 3.78–3.82 (t, 12H, CH2O), δ 7.17–7.20 (d, 2H, ArH), δ 7.36–7.39 (d, 2H, ArH); 13C NMR (75.48 MHz, CDCl3) δ 10.80 (CHSi), δ 18.46 (CH3), δ 29.47 (CHPh), δ 58.66 (CH2O), δ 130.84, 131.10 (CH aromatic); EI-MS (m/z) 508 (5%, M+), 464 (100%, [M+−44]).

Fuente