Reacción #1144435

Ecuación de reacción

5-ethyluracil

potassium carbonate

→

1-butyl-5-ethyluracil

Rendimiento 69.0%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated under reduced pressure
2. 2
   Concentraciónthe organic layer was concentrated under reduced pressure
3. 3
   Lavadoeluted with 30% ethyl acetate/hexane

Procedimiento

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

Fuente