Reacción #1142858

Ecuación de reacción

compound

1-(2,2-Diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

1-bromo-3-nitrobenzene

→

title compound

1-(2,2-Diethoxyethyl)-N-(3-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Condiciones de reacción

Procedimiento

Analogously to the process described under Example 6A/Step 1, 1.0 g (3.62 mmol) of the compound of Example 4A and 804 mg (3.98 mmol) of 1-bromo-3-nitrobenzene gave 1.26 g (87% of theory) of the title compound. In this case, chromatographic isolation of the product was by MPLC (mobile phase cyclohexane/ethyl acetate 1:2); subsequent trituration with diisopropyl ether was dispensed with.

Fuente