Reacción #1142815

Ecuación de reacción

compound

1-(2,2-Diethoxyethyl)-1′-(4-methoxybenzyl)-1H,1′H-3,4′-bipyrazol-5-amine

→

6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazole

Disolventes

ethanol

sulphuric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was then purified directly by preparative HPLC (Method 11)
2. 2
   ConcentraciónThe product fractions were concentrated
3. 3
   Otrothe residue was dried under high vacuum

Procedimiento

In a microwave oven (Biotage Initiator, with Dynamic Field Tuning), 155 mg (0.40 mmol) of the compound of Example 2A in 0.4 ml of ethanol and 0.2 ml of 2 M sulphuric acid were heated at 120° C. for 15 min. The reaction was then purified directly by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 54 mg (46% of theory) of the title compound.

Fuente