Reacción #1142814

Ecuación de reacción

3-oxo-3-(pyridin-3-yl)propionitrile

(2,2-diethoxyethyl)hydrazine

hydrochloric acid

→

1-(2,2-Diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Disolventes

ethyl acetate

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was heated
2. 2
   Temperaturaunder reflux for 4 h
3. 3
   Otroall volatile components were then substantially removed on a rotary evaporator
4. 4
   OtroThe residue obtained
5. 5
   Lavadothe solution was washed with water
6. 6
   Secadodried over anhydrous magnesium sulphate
7. 7
   FiltraciónAfter filtration
8. 8
   Otrothe mixture was evaporated to dryness
9. 9
   OtroThe residue that remained was triturated with diisopropyl ether at RT
10. 10
    FiltraciónThe resulting solid was then filtered off with suction
11. 11
    Otrodried under high vacuum

Procedimiento

With gentle heating, 125 g (812 mmol, purity 95%) of 3-oxo-3-(pyridin-3-yl)propionitrile [lit. for example: P. Seneci et al., Synth. Commun. 1999, 29 (2), 311-341; also available commercially] were dissolved in 1.25 liters of ethanol. 126 g (853 mmol) of (2,2-diethoxyethyl)hydrazine and 4.1 ml (4.06 mmol) of 1 M hydrochloric acid were then added. The reaction mixture was heated under reflux for 4 h, and all volatile components were then substantially removed on a rotary evaporator. The residue obtained was taken up in ethyl acetate, and the solution was washed with water and dried over anhydrous magnesium sulphate. After filtration, the mixture was evaporated to dryness. The residue that remained was triturated with diisopropyl ether at RT. The resulting solid was then filtered off with suction and dried under high vacuum. This gave 153 g (65% of theory, purity 96%) of the title compound.

Fuente