Reacción #1140124

Ecuación de reacción

(S)-naproxen

(−)-tramadol

→

(−)-tramadol (S)-naproxen

Rendimiento 100.0%

Disolventes

methanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was evaporated under vacuum
2. 2
   TemperaturaThe oil was cooled to −197° C.
3. 3
   Temperaturato warm to room temperature

Procedimiento

A solution of (S)-naproxen (2.14 g, 9.3 mmol) in 20 mL of methanol was added in 10 minutes to a stirred solution of (−)-tramadol (2.45 g, 9.3 mmol) in 10 mL of methanol. The resulting solution was stirred at room temperature for 30 minutes and the solvent was evaporated under vacuum rendering a light yellow oil. The oil was cooled to −197° C. and allowed to warm to room temperature to give the amorphous (−)-tramadol-(S)-naproxen salt as a white solid (4.59 g, 100%).

Fuente