Reacción #11381

Ecuación de reacción

potassium carbonate

2-chloro-3-nitropyridine

cyclohexylamine

→

N-Cyclohexyl-3-nitro-2-pyridineamine

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe solution is then extracted with 200 ml of ether
2. 2
   Lavadothe organic phase is washed three times with water
3. 3
   SecadoAfter drying over magnesium sulphate
4. 4
   Otrothe ether is evaporated off

Procedimiento

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

Fuente