Reacción #11365

Ecuación de reacción

bromoacetyl bromide

compound

2-(2-Ethoxyphenyl)-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

AlCl3

→

2-[5-(2-Bromoacetyl)-2-ethoxyphenyl]-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaat reflux for 2 h
3. 3
   Extracciónextraction with CH2Cl2
4. 4
   Secadodrying over MgSO4 and concentration under reduced pressure
5. 5
   Otrothe residue was triturated with ether
6. 6
   OtroThis gave 1.33 g (33% pure according to LC-MS) of the desired product which was reacted further without further purification

Procedimiento

A solution, cooled to 0° C., of 1 g (3.1 mmol) of the compound from example 17A in 80 ml of CH2Cl2 was admixed dropwise with 1.2 g (6.1 mmol) of bromoacetyl bromide and a little at a time with 1.2 g (9.1 mmol) of AlCl3. The reaction mixture was warmed to room temperature (30 min.) and then heated at reflux for 2 h and carefully poured into ice-water. Following extraction with CH2Cl2, drying over MgSO4 and concentration under reduced pressure, the residue was triturated with ether. This gave 1.33 g (33% pure according to LC-MS) of the desired product which was reacted further without further purification.

Fuente