Reacción #1135841

Ecuación de reacción

methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate

Rendimiento 67.7%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated
2. 2
   OtroThe residue was purified by biotage column chromatography

Procedimiento

To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)

Fuente