Reacción #1135839

Ecuación de reacción

N-cyclopropyl-2-nitroaniline

ammonium formate

→

N1-cyclopropylbenzene-1,2-diamine

Rendimiento 97.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturato reflux under a nitrogen atmosphere overnight
3. 3
   Filtraciónfiltered
4. 4
   ConcentraciónThe filtrate was concentrated
5. 5
   Otropurified by biotage column chromatography

Procedimiento

To a solution of N-cyclopropyl-2-nitroaniline (365 mg, 2.05 mmol) and ammonium formate (516 mg, 8.2 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give N1-cyclopropylbenzene-1,2-diamine (296 mg)

Fuente