Reacción #1135835

Ecuación de reacción

methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate

ammonium formate

→

methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate

Rendimiento 85.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturato reflux under a nitrogen atmosphere overnight
3. 3
   Filtraciónfiltered
4. 4
   ConcentraciónThe filtrate was concentrated
5. 5
   Otropurified by biotage column chromatography

Procedimiento

To a solution of methyl 8-(4-nitrobiphenyl-3-ylamino)-8-oxooctanoate (270 mg, 0.70 mmol) and ammonium formate (177 mg, 2.8 mmol) in methanol was added catalytic amount of palladium on carbon (5%). The mixture was heated to reflux under a nitrogen atmosphere overnight and filtered. The filtrate was concentrated and purified by biotage column chromatography to give methyl 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (211 mg)

Fuente