Reacción #1135831

Ecuación de reacción

methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate

Rendimiento 84.3%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated
2. 2
   OtroThe residue was purified by biotage column chromatography

Procedimiento

To a solution of methyl 8-(2-amino-4-bromophenylamino)-8-oxooctanoate (140 mg, 0.395 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(5-bromo-1H-benzimidazol-2-yl)heptanoate (113 mg)

Fuente