Reacción #1135812

Ecuación de reacción

2-methyl-3-nitrophenol

iodoethane

potassium carbonate

→

1-ethoxy-2-methyl-3-nitrobenzene

Rendimiento 100.7%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawith heating
2. 2
   Temperaturaunder reflux for ten hours
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónthe resulting filtrates were concentrated
5. 5
   ExtracciónThe resulting mixtures were extracted with ethyl acetate
6. 6
   Lavadothe organic layers were washed with water and saturated saline
7. 7
   Secadowere dried over anhydrous magnesium sulfate
8. 8
   Concentraciónwere then concentrated under reduced pressure

Procedimiento

A mixture of 2-methyl-3-nitrophenol 33.5 g, iodoethane 41 g and potassium carbonate 90 g in acetone 400 mL was stirred with heating under reflux for ten hours. The mixtures were cooled to room temperature and filtered and the resulting filtrates were concentrated. The resulting mixtures were extracted with ethyl acetate and the organic layers were washed with water and saturated saline, and were dried over anhydrous magnesium sulfate and were then concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give 1-ethoxy-2-methyl-3-nitrobenzene 39.9 g.

Fuente