Reacción #1135805

Ecuación de reacción

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroTo the reaction mixtures
2. 2
   Extracciónthe mixtures were extracted with ethyl acetate
3. 3
   LavadoThe organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   Secadowere dried over anhydrous sodium sulfate
5. 5
   ConcentraciónThe resulting mixtures were concentrated under reduced pressure

Procedimiento

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

Fuente