Reacción #1135797

Ecuación de reacción

methyl chloroformate

tetrahydrofuran

1-chloro-2-methyl-3-aminobenzene

→

1-chloro-2-methyl-3-methoxycarbonylaminobenzene

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroTo the reaction mixtures
2. 2
   Extracciónthe resulting mixtures were extracted with ethyl acetate
3. 3
   LavadoThe organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   Secadowere dried over anhydrous sodium sulfate
5. 5
   ConcentraciónThe mixtures were concentrated under reduced pressure

Procedimiento

Under cooling, to a mixture of methyl chloroformate 30 mL and tetrahydrofuran 50 mL was added dropwise 1-chloro-2-methyl-3-aminobenzene 5.00 g and the mixtures were stirred at 25° C. for a half hour. To the reaction mixtures was added water and the resulting mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The mixtures were concentrated under reduced pressure to give 1-chloro-2-methyl-3-methoxycarbonylaminobenzene 5.80 g.

Fuente