Reacción #11264

Ecuación de reacción

phosphorus oxychloride

ethylacetoacetate

cyanoacetamide

→

3-cyano-2,5-dihydroxy-4-methylpyridine

Condiciones de reacción

Procedimiento

Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).

Fuente