Reacción #1126303

Ecuación de reacción

methyl hydrazinecarbothioate

piperidin-4-ol

ethyl acetate

→

crude desired product

1-hydrazinothiocarbonylpiperidin-4-ol

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe reaction solution was washed with saturated aqueous sodium chloride
2. 2
   Secadodried over anhydrous magnesium sulfate
3. 3
   Concentraciónconcentrated

Procedimiento

A solution of methyl hydrazinecarbothioate (1.0 g, 8.2 mmol) and piperidin-4-ol (1.24 g, 12.3 mmol) in ethanol (7 mL) was refluxed with heating at 90° C. for 2 days. After addition of ethyl acetate, the reaction solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product. The crude product was used directly for the next reaction.

Fuente