Reacción #1122769

Ecuación de reacción

hydrochloric acid

sodium nitrite

4-bromo-2-methoxy-6-methylaniline

hypophosphoric acid

→

1-Bromo-3-methoxy-5-methylbenzene

Disolventes

water

acetic acid

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction is performed in a water/ice bath
2. 2
   workup.STIRRINGThe reaction is stirred at 0° C. for 8 hours
3. 3
   workup.WAITto stand at RT over night

Procedimiento

The reaction is performed in a water/ice bath. 500 mg (2.31 mmol, 1 eq) of 4-bromo-2-methoxy-6-methylaniline is dissolved in a mixture of 7 ml of acetic acid and 3 ml of water, followed by adding 0.8 ml of concentrated hydrochloric acid (37%) and 207 mg (3.00 mmol, 1.5 eq) of sodium nitrite dissolved in 1 ml of water. The mixture is stirred for 30 min and subsequently added to 8 ml of ice-cooled 50% by weight hypophosphoric acid. The reaction is stirred at 0° C. for 8 hours and allowed to stand at RT over night.

Fuente