Reacción #1122380

Ecuación de reacción

29D

1-(4-(Azetidin-3-yloxy)-2-fluorobenzyl)-4-methylpiperazine

ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate

→

29

Rendimiento 32.0%

1-[2-Fluoro-4-({1-[(5-phenyl-1,3,4-oxadiazol-2-yl)carbonyl]azetidin-3-yl}oxy)benzyl]-4-methylpiperazine

Rendimiento 32.0%

Condiciones de reacción

Procedimiento

Using a similar protocol as described in Example 10 employing 29D (0.10 g, 0.36 mmol) and ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate (0.11 g, 0.43 mmol) as starting materials afforded 52 mg (30%) of 29 as a foam.

Fuente