Reacción #1122

ord-4950a24c3bb24e6eb853f7c03d0888b7

Ecuación de reacción

CC(C)c1nccc(N)c1Cl
4-amino-3-chloro-2-isopropylpyridine
O=C1CCC(c2ccccc2)CC1
4-phenylcyclohexanone
→
CC(C)c1nccc(N[C@H]2CC[C@@H](c3ccccc3)CC2)c1Cl
3-Chloro-2-isopropyl-4-(cis-4-phenylcyclohexylamino)pyridine
Rendimiento 26.6%

Reactantes

CC(C)c1nccc(N)c1Cl
4-amino-3-chloro-2-isopropylpyridine
O=C1CCC(c2ccccc2)CC1
4-phenylcyclohexanone

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Was prepared analogously to Example 75 starting from 4-amino-3-chloro-2-isopropylpyridine and 4-phenylcyclohexanone. Yield: 26.6%

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05723450uspto-grants-1998_03