Reacción #1121781

Ecuación de reacción

231

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one

acetyl chloride

→

25a

Rendimiento 66.0%

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3-yl acetate

Rendimiento 66.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThen the solution was washed with water
2. 2
   Secadothe organic layer was dried over Na2SO4
3. 3
   Filtraciónfiltered
4. 4
   Otrothe solvent removed under reduced pressure

Procedimiento

To a solution of 231 (25 mg, 0.06 mmol) in 4 mL of dichloromethane, acetyl chloride (8 μL, 0.12 mmol) and 4-(dimethylamino)pyridine (DMAP) (5 mg, 0.03 mmol) were added, the resulting mixture was stirred at room temperature for 15 min. Then the solution was washed with water and the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to obtain 18 mg (yield 66%) of 25a as a red oil. 1H-NMR (CDCl3): 2.10 (s, 3H), 3.88 (s, 3H), 4.20 (s, 2H), 7.00-7.02 (m, 2H), 7.22-7.33 (m, 8H), 7.61-7.64 (m, 4H), 7.68 (s, 1H). MS (ESI): m/z 482 (M+H+).

Fuente