Reacción #1121718

Ecuación de reacción

acetophenone

4-tert-butylbenzoyl chloride

→

1-phenylvinyl 4-tert-butylbenzoate

Rendimiento 57.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITThe mixture was then left
2. 2
   Temperaturato cool
3. 3
   Extracciónextracted with dichloromethane
4. 4
   SecadoThe organic phase was dried over magnesium sulfate
5. 5
   Otrothe solvent was removed under reduced pressure
6. 6
   OtroA 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1)

Procedimiento

A mixture of 4.16 g (21.62 mmol) of acetophenone trimethylsilylenol, 4.33 g (22.01 mmol) of 4-tert-butylbenzoyl chloride and 136 mg of mercuric chloride was heated at 100° C. for 2 h. The mixture was then left to cool, water was added over the reaction crude and extracted with dichloromethane. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1) giving 1.17 g of 1-phenylvinyl 4-tert-butylbenzoate. Yield 57%.

Fuente