Reacción #1120075

Ecuación de reacción

carbobenzoxy-(S)-valine

3,5-dibromosalicylaldehyde

→

N-(3,5-dibromosalicylidene)-(S)-valine

Rendimiento 68.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe desired product was prepared in the same manner as the latter half procedure of Reference Example 1

Procedimiento

The desired product was prepared in the same manner as the latter half procedure of Reference Example 1. That is, carbobenzoxy-(S)-valine piperizide (0.32 g, 1 mmol) was hydrogenated and then condensed with 3,5-dibromosalicylaldehyde (0.42 g, 1.5 mmol) to obtain 0.30 g (68%) of the desired N-(3,5-dibromosalicylidene)-(S)-valine piperizide, which was further recrystallized from methanol. m.p. 143.2°-145.4° C. [α]26D +50.1° (c 0.97, CHCl3)

Fuente