Reacción #1107

Ecuación de reacción

4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine

→

4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

Disolventes

water

methanol

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroare hydrogenated at room temperature
2. 2
   Otronormal pressure until absorption of hydrogen
3. 3
   FiltraciónAfter filtering
4. 4
   Concentraciónconcentrating 1 g of syrup

Procedimiento

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

Fuente