Reacción #1106678

Ecuación de reacción

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine

sulfamide

Chloroform

→

title compound

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)sulfamide

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux overnight
3. 3
   Otrothe precipitate was removed by filtration
4. 4
   ConcentraciónThe filtrate was concentrated under vacuum
5. 5
   Otropurified by chromatography (2% to 8% acetone in dichloromethane)

Procedimiento

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine (2.90 g, 16.2 mmol) and sulfamide (3.11 g, 32.4 mmol) were combined in dry dioxane (60 ml) and heated to reflux overnight. Chloroform was added and the precipitate was removed by filtration. The filtrate was concentrated under vacuum and purified by chromatography (2% to 8% acetone in dichloromethane) to yield the title compound as an off-white solid.

Fuente