Reacción #1106664

Ecuación de reacción

1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone

N,N-dimethylethylenediamine

→

Compound 1

1,4-bis(2-(dimethylamino)ethylamino)-2,3-difluoro-5,8-dihydroxyanthracene-9,10-dione

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter evaporation of the solvents
2. 2
   Otrothe residue was purified by silica gel chromatography

Procedimiento

A mixture of 1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone (1.0 g, 3.2 mmol) and N,N-dimethylethylenediamine (3 mL) in CH2Cl2 (30 mL) was stirred at room temperature for 12 hours. After evaporation of the solvents, the residue was purified by silica gel chromatography using isocratic solvent system of EtOAc/MeOH/Et3N (10:10:1) yielding 830 mgs of Compound 1 as dark blue product. Abs (max, PBS pH 7.4)=568 nm; Em=675 nm. The structure of Compound 1 is given below:

Fuente