Reacción #1106454

ord-91ba6d6243b146c292ab57c12204374b

Ecuación de reacción

O=S(=O)([O-])[O-].[Zn+2]
Zinc sulphate
O
water
O
water
Cc1ccccn1
Alpha picoline
O=S(=O)(O)O
sulphuric acid
O=[N+]([O-])O
Nitric acid
→
O=C([O-])c1ccccn1.O=C([O-])c1ccccn1.[Zn+2]
zinc picolinate
Rendimiento 21.0%

Reactantes

O=S(=O)([O-])[O-].[Zn+2]
Zinc sulphate
O
water
O
water
Cc1ccccn1
Alpha picoline
O=S(=O)(O)O
sulphuric acid
O=[N+]([O-])O
Nitric acid

Reactivos

Ninguno

Condiciones de reacción

Temperatura
180°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.ADDITIONAfter the addition
  2. 2
    Temperaturathe temperature was maintained at the same level for 20 hours
  3. 3
    Temperaturawas cooled to ambient temperature
  4. 4
    workup.ADDITIONwas added slowly
  5. 5
    FiltraciónThe precipitate was filtered
  6. 6
    Lavadowashed
  7. 7
    Otrodried

Procedimiento

Alpha picoline 1.0 kg was slowly added to concentrated solution of sulphuric acid under agitation. After the addition was completed the mass temperature was raised to 180° C. and 6.0 kg of 70% Nitric acid was added and the temperature was maintained at the same level for 20 hours. After the reaction was over mass was cooled to ambient temperature and three times water was added. pH of the reaction mass was adjusted to 5.0. Zinc sulphate 600 grams dissolved in water was added slowly and the whole mass was stirred till a white precipitate appeared. The precipitate was filtered washed and dried to give 800 grams of zinc picolinate having 21% Zinc content (Desired limit 19-22%)

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06486318B1uspto-grants-2002_11