Reacción #1106

Ecuación de reacción

4-chloro-3-methoxy-2-methylpyridine

4-tert-butylaniline

NaOH

→

4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Disolventes

phenol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónthe product is extracted
3. 3
   ConcentraciónAfter concentrating
4. 4
   workup.DISTILLATIONthe excess of amine is distilled off in vacuo
5. 5
   Otrothe residue is crystallized

Procedimiento

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

Fuente