Reacción #11052

Ecuación de reacción

intermediate 1i

{6-[4-(tert-butoxycarbonylamino-imino-methyl)-benzylcarbamoyl]-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-3-yl}-carbamic acid benzyl ester

→

intermediate 1j

Rendimiento 84.0%

(S)-[(4-{[(3-amino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carbonyl)-amino]-methyl}-phenyl)-imino-methyl]-carbamic acid tert-butyl ester

Rendimiento 84.0%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was evacuated
2. 2
   Otroflushed with H2 (3×)
3. 3
   FiltraciónThe mixture was filtered
4. 4
   Concentraciónconcentrated

Procedimiento

To a solution of intermediate 1i (74.8 mg, 0.134 mmol) in 3 mL MeOH, was added 80 mg 10% Pd/C. The mixture was evacuated and flushed with H2 (3×), then it was stirred under an atmosphere of H2 for 24 h. The mixture was filtered and concentrated to afford 48 mg (84%) of intermediate 1j. MS (ESI) 427.08 (M+H+).

Fuente