Reacción #1102147

Ecuación de reacción

2-{3-[1-((2-chloro)phenoxycarbanoyl)piperidin-4-yl]propyn-1-yl}adenosine

NaOH

→

product

4-[3-(6-Amino-9H-purin-2-yl)-prop-2-ynyl]-piperidine-1-carboxylic acid 2-chloro-phenyl Ester

Disolventes

methanol

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe methanol removed under reduced pressure
2. 2
   TemperaturaAfter cooling the resulting precipitate
3. 3
   Filtraciónwas filtered
4. 4
   Lavadowashed with water

Procedimiento

A solution of 2-{3-[1-((2-chloro)phenoxycarbanoyl)piperidin-4-yl]propyn-1-yl}adenosine (0.720 g, 1.326 mmol) in methanol (25 mL) and 1.0 M HCl (2.50 mL) was stirred at 90° C. in a pressure apparatus for 22 h. The pH was adjusted to 5 with 1.0 M NaOH and the methanol removed under reduced pressure. After cooling the resulting precipitate was filtered and washed with water to afford the pure product as a white solid: yield 1.481 g, 88%.

Fuente