Reacción #1100488

Ecuación de reacción

solution

methyl 3-bromo-4-o-tolyl-1H-indole-2-carboxylate

1-(3-bromopropoxy)naphthalene

cesium carbonate

→

title product

methyl 3-bromo-1-(3-(naphthalen-1-yloxy)propyl)-4-o-tolyl-1H-indole-2-carboxylate

Disolventes

N,N-dimethylformamide

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water
2. 2
   SecadoThe organic layer was dried over sodium sulfate
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe residue was purified by flash chromatography
6. 6
   Lavadoeluting with 0-50% dichloromethane in hexane

Procedimiento

To a solution of EXAMPLE 126B (1.14 g) and 1-(3-bromopropoxy)naphthalene (0.922 g) in N,N-dimethylformamide (20 ml) was added cesium carbonate (2.158 g). The reaction was stirred at room temperature overnight and diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography, eluting with 0-50% dichloromethane in hexane to provide the title product.

Fuente