Reacción #1100112

ord-213e38fd84ac4d209f58806cd302badf

Ecuación de reacción

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
c1ccc2sccc2c1
thianaphthene
→
O=C1COc2ccc(CN[C@H]3CC[C@H](C(=O)c4cc5ccccc5s4)CC3)cc2N1
title compound
O=C1COc2ccc(CN[C@H]3CC[C@H](C(=O)c4cc5ccccc5s4)CC3)cc2N1
6-{[trans-4-(benzo[b]thiophene-2-carbonyl)-cyclohexylamino]-methyl}-4H-benzo[1,4]oxazin-3-one

Reactantes

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
—
1.c
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
c1ccc2sccc2c1
thianaphthene

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared according to the same protocol as that described for example 1, steps 1.a to 1.c, starting from thianaphthene (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde (0.4 mmol). A colourless solid (44 mg) was obtained.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07981886B2uspto-grants-2011_07