Reacción #1100103

ord-a7ce56630155459286ed9c6b10670c7e

Ecuación de reacción

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
COc1cccc2scnc12
4-methoxy-benzothiazole
→
COc1cccc2sc(C(=O)[C@H]3CC[C@H](NCc4ccc5c(c4)NC(=O)CO5)CC3)nc12
title compound
COc1cccc2sc(C(=O)[C@H]3CC[C@H](NCc4ccc5c(c4)NC(=O)CO5)CC3)nc12
6-{[trans-4-(4-methoxy-benzothiazole-2-carbonyl)-cyclohexylamino]-methyl}-4H-benzo[1,4]oxazin-3-one

Reactantes

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
—
1.c
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
COc1cccc2scnc12
4-methoxy-benzothiazole

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared according to the same protocol as that described for example 1, steps 1.a to 1.c, using 4-methoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde (0.3 mmol). An orange solid (74 mg) was obtained.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07981886B2uspto-grants-2011_07