Reacción #1099628

Ecuación de reacción

water

Bromine

1-(2,6-difluorophenyl)ethanone

aluminum chloride

→

title compound

Rendimiento 100.0%

2-bromo-1-(2,6-difluorophenyl)ethanone

Rendimiento 100.0%

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGAfter stirring at room temperature for 2 hr
2. 2
   Extracciónthe mixture was extracted with ethyl acetate
3. 3
   LavadoThe obtained organic layer was washed with saturated brine
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 1-(2,6-difluorophenyl)ethanone (10.0 g) in diethyl ether (50 mL) was added anhydrous aluminum chloride (86 mg) and the mixture was stirred for 5 min. Bromine (3.3 mL) was added dropwise at 10-15° C. After stirring at room temperature for 2 hr, the mixture was poured into water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, concentrated under reduced pressure to give the title compound as a pale-yellow oil (yield 15.2 g, about 100%).

Fuente