Reacción #10877

ord-63144ce9652240199f91e9d2e6bc1107

Ecuación de reacción

O=[N+]([O-])c1ccc(N2CCN(CCO)CC2)cc1
4-(4-nitrophenyl)-1-piperazine-ethanol
[N-]=C=S
isothiocyanate
→
OCCN1CCN(c2ccc(N=C=S)cc2)CC1
4-(2-Hydroxyethyl)-1-(4-isothiocyanatophenyl)piperazine

Reactantes

O=[N+]([O-])c1ccc(N2CCN(CCO)CC2)cc1
4-(4-nitrophenyl)-1-piperazine-ethanol
[N-]=C=S
isothiocyanate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroforming reactions

Procedimiento

This compound was prepared from 4-(4-nitrophenyl)-1-piperazine-ethanol (Bionet Research Ltd.) using the hydrogenation and isothiocyanate-forming reactions used in Example 4.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07094896B2uspto-grants-2006_08