Reacción #10864

Ecuación de reacción

2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile

→

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Disolventes

chlorobenzene

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter filtration and evaporation

Procedimiento

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile (0.323 g) and cupric chloride (0.175 g) was heated in chlorobenzene at 60° C. for 6 hours. After filtration and evaporation, the title compound and 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole were obtained as a 7:1 mixture. Column chromatography on silica gel eluting with dichloromethane gave the pure title compound, obtained as a mixture of syn and anti isomers, NMR (anti isomer) 3.6 (s, 2H), 7.57 (s, 2H), 8.82 (s, 1H, exchangeable with D2O), NMR (syn isomer) 3.56 (s, 2H), 7.59 (s, 2H), 8.27 (s, 1H, exchangeable with D2O).

Fuente