Reacción #1075280

Ecuación de reacción

1H-indole

NaH

6-bromo-1-methanesulfonyl-1H-indole

N-methylpiperidine-2-methanol

potassium carbonate

6-bromo-1-(N-methyl-azepan-3-yl)-1H-indole

→

6-(4-hydroxy-tetrahydropyran-4-yl)-1-(2-(N,N-dimethylamino)ethyl)-1H-indole

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat 100° C.
2. 2
   Otroovernight

Procedimiento

6-Bromo-1-(N-methylpiperidin-2-yl)methyl)-1H-indole (220 mg, 57.2%) and 6-bromo-1-(N-methyl-azepan-3-yl)-1H-indole (94 mg, 24.4%); from 6-bromo-1-methanesulfonyl-1H-indole (344 mg, 1.25 mmol) and N-methylpiperidine-2-methanol (395 mg, 2.5 mmol) with NaH (53 mg, 2.2 mmol) and potassium carbonate (325 mg, 2.35 mmol) in toluene (10 mL) at 100° C. overnight.

Fuente