Reacción #1069767

Ecuación de reacción

N,N-diethyl-p-nitrosoaniline

3-phenyl-1-(2-pyridyl)-5-aminopyrazole

→

7-diethylamino-3-phenyl-1-(2-pyridyl)-1H-pyrazolo[3,4-b]quinoxaline

Rendimiento 33.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated to half volume
2. 2
   workup.ADDITIONWater was added
3. 3
   Otroto get a precipitate
4. 4
   Filtraciónfiltered
5. 5
   OtroThe solid was purified by chromatograph column on silica gel
6. 6
   OtroAfter removing the solvent

Procedimiento

1.78 g N,N-diethyl-p-nitrosoaniline and 2.67 g 3-phenyl-1-(2-pyridyl)-5-aminopyrazole were refluxed for 2 hrs in acetic acid. The mixture was concentrated to half volume. Water was added to get a precipitate, then filtered. The solid was purified by chromatograph column on silica gel. After removing the solvent, 1.3 g pure 7-diethylamino-3-phenyl-1-(2-pyridyl)-1H-pyrazolo[3,4-b]quinoxaline (DEPPPQ) was obtained as brown-red solid.

Fuente