Reacción #1069765

Ecuación de reacción

Na2CO3

2-hydrazinopyridine

benzoylacetonitrile

→

1-pyridyl-3-phenyl-5-aminopyrazole

Rendimiento 80.5%

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was refluxed for 3 hrs
2. 2
   TemperaturaAfter cooling
3. 3
   FiltraciónThe yellow precipitate was filtrated
4. 4
   Lavadowashed with H2O
5. 5
   Otrodried

Procedimiento

To a solution of 1.09 g 2-hydrazinopyridine in 10 ml 5N hydrochloric acid was added 1.45 g benzoylacetonitrile (from Example 2) under stirring. The mixture was refluxed for 3 hrs. After cooling, the solution was neutralized with Na2CO3. The yellow precipitate was filtrated, washed with H2O, and dried to get 1.9 g 1-pyridyl-3-phenyl-5-aminopyrazole.

Fuente