Reacción #1069763

Ecuación de reacción

NaOH

sodium

benzoylacetaldehyde

hydroxyamine chloride

→

benzoylacetonitrile

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was then refluxed for 24 hrs
2. 2
   Concentraciónconcentrated to 2/3 volume
3. 3
   FiltraciónThe precipitate was collected by filtration
4. 4
   Otrodried under vacuum

Procedimiento

To a solution of 10 g sodium salt of benzoylacetaldehyde (prepared according to the procedure of Example 1) and 10 g hydroxyamine chloride in 30 ml ethanol was added 20 ml 50% NaOH at 0-10° C. The mixture was then refluxed for 24 hrs, and concentrated to 2/3 volume. The brown solution was neutralized with the concentrated hydrochloric acid. The precipitate was collected by filtration, and dried under vacuum to get a solid with slight pink color, 3.8 g benzoylacetonitrile.

Fuente