Reacción #10687

ord-6c378cc1f8624b089d5efbafe5b55132

Ecuación de reacción

[CH3][Sn]([CH3])([CH3])[CH3]
tetramethyltin
Nc1cccc2c(O)ncc(Br)c12
Intermediate 138
Nc1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-aminoisoquinoline
→
Cc1cnc(O)c2cccc(N)c12
title compound
Cc1cnc(O)c2cccc(N)c12
1-hydroxy-4-methyl-5-aminoisoquinoline

Reactantes

[CH3][Sn]([CH3])([CH3])[CH3]
tetramethyltin
Nc1cccc2c(O)ncc(Br)c12
Intermediate 138
Nc1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-aminoisoquinoline

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

According to the method of Example 106, Step A, a methylation reaction with tetramethyltin was performed by using Intermediate 138 to obtain the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07094789B2uspto-grants-2006_08