Reacción #1068535

Ecuación de reacción

2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione

sodium iodide

→

crude title compound

Rendimiento 98.8%

2-Bromo-6-methylenandrost-4-ene-3,17-dione

Rendimiento 98.8%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 250 ml 3-necked round bottomed flask fitted with a condenser
2. 2
   TemperaturaThe resulting suspension in refluxed for 15 min
3. 3
   Filtraciónfiltered
4. 4
   Otroevaporated in vacuo
5. 5
   Lavadowashed twice with a saturated sodium thiosulfate aqueous solution, twice with water
6. 6
   Secadodried over anhydrous calcium chloride
7. 7
   OtroEvaporation of the solvent in vacuo

Procedimiento

A 250 ml 3-necked round bottomed flask fitted with a condenser, a thermometer and a magnetic stirrer is charged with 2.68 g of 2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione, 100 ml of acetone and 5.99 g of sodium iodide. The resulting suspension in refluxed for 15 min, cooled to room temperature, filtered and evaporated in vacuo. The residue is taken up with 50 ml of chloroform, washed twice with a saturated sodium thiosulfate aqueous solution, twice with water and dried over anhydrous calcium chloride. Evaporation of the solvent in vacuo yields 1.86 g of the crude title compound which is directly used for the next step.

Fuente