Reacción #10646

Ecuación de reacción

Tin(II) chloride dihydrate

Intermediate 89

4-chloro-5-nitroisoquinoline

sodium hydroxide

→

title compound

Rendimiento 67.5%

4-chloro-5-aminoisoquinoline

Rendimiento 67.5%

Disolventes

hydrochloric acid

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed
2. 2
   Temperaturawith heating for 2 hours
3. 3
   Extracciónextracted twice with chloroform (20 ml for each time)
4. 4
   SecadoThe organic layer was dried over anhydrous sodium sulfate
5. 5
   Otrothe solvent was evaporated under reduced pressure

Procedimiento

Tin(II) chloride dihydrate (1.70 g) was dissolved in concentrated hydrochloric acid (1 ml), added with a mixture of Intermediate 89 (315 mg) and 2 N aqueous hydrochloric acid (2 ml) with ice cooling and refluxed with heating for 2 hours. The reaction mixture was cooled to room temperature, added with 5 N aqueous sodium hydroxide (7 ml) and extracted twice with chloroform (20 ml for each time). The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain the title compound (182 mg).

Fuente