Reacción #10641

Ecuación de reacción

Intermediate 85

N-(tert-butoxycarbonyl)-N′-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine

hydrogen chloride methanol

→

title compound

N-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otro(50° C., 2 hours)
2. 2
   Otrothe solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
4. 4
   OtroThe deposited precipitates
5. 5
   Filtraciónwere collected by filtration
6. 6
   Lavadowashed with diethyl ether

Procedimiento

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 85 (85.5 mg) and 10% hydrogen chloride/methanol solution (2 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (52.3 mg).

Fuente