Reacción #1061899

Ecuación de reacción

sodium bicarbonate

3-hydroxy-4-methoxybenzoic acid

sulfuric acid

→

desired product

Methyl 3-hydroxy-4-methoxybenzoate

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe aqueous mixture was then extracted three times with ethyl acetate
2. 2
   Lavadowashed with water and brine
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   OtroRotary evaporation of the solution

Procedimiento

A mixture of 3-hydroxy-4-methoxybenzoic acid (Aldrich, 10 g, 59.5 mmol), methanol (250 ml) and concentrated sulfuric acid (1 ml) was stirred overnight and the product was poured into a mixture of sodium bicarbonate and ice. The aqueous mixture was then extracted three times with ethyl acetate. The resulting organic layers were combined, washed with water and brine, and dried over anhydrous magnesium sulfate. Rotary evaporation of the solution gave 9.5 g of the desired product as a colorless oil. NMR (δ):3.89 (s, 3H), 3.95 (s, 3H).

Fuente