Reacción #1061891

Ecuación de reacción

tetrahydrofuran

4-hydroxypyridine

sodium hydride

Octyl bromide

→

1-octyl-4-pyridone

Disolventes

brine

ethyl acetate

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was separated
2. 2
   Secadodried over magnesium sulfate
3. 3
   FiltraciónThe magnesium sulfate was filtered off
4. 4
   Otrothe filtrate was evaporated under reduced pressure

Procedimiento

To a suspension of sodium hydride (2.04 g) in N,N-dimethylformamide (50 ml) was added 4-hydroxypyridine (5 g) at room temperature. Octyl bromide (9.08 ml) was added thereto. The mixture was stirred for 2 hours at 50° C. The reaction mixture was added to a mixture of brine (100 ml), tetrahydrofuran (100 ml) and ethyl acetate (100 ml). The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-octyl-4-pyridone (14.7 g).

Fuente