Reacción #10562

Ecuación de reacción

ethyl 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carboxylate

trifluoroacetic acid

→

title compound

Rendimiento 100.6%

Ethyl 6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate

Rendimiento 100.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled
2. 2
   Filtraciónthe solid was collected by filtration
3. 3
   LavadoThe filter cake was washed with absolute ethanol (350 ml)
4. 4
   Otrowas then dried in vacuo at 50° C.

Procedimiento

To a suspension of ethyl 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carboxylate (Preparation 62) (250 g, 0.530 moles) in absolute ethanol (1250 ml) under an atmosphere of nitrogen was added trifluoroacetic acid (73.5 g, 0.645 moles) and the resultant mixture was heated at 50° C. for 20 hours. The mixture was cooled and the solid was collected by filtration. The filter cake was washed with absolute ethanol (350 ml) and was then dried in vacuo at 50° C. to give the title compound (206.5 g) as a cream coloured fine powder, m.p. >200° C.

Fuente